This medicine should also come with a Medication Guide. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. Ask your doctor if you have any questions.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Keep from freezing. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations.
Here is the link to the FDA safe disposal of medicines website: www. It is very important that your doctor check your progress while you are using this medicine, especially within the first 24 to 72 hours of treatment. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects. This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose.
Call your doctor for instructions. If you think you or someone else may have taken an overdose of this medicine, get emergency help at once.
Your doctor may also give naloxone to treat an overdose. Signs of an overdose include: cold, clammy skin, coughing that sometimes produces a pink frothy sputum, dark urine, difficult or trouble breathing, irregular, fast or slow, or shallow breathing, nausea, vomiting, pain in the upper stomach, pale or blue lips, fingernails, or skin, pinpoint pupils of the eyes, or yellow eyes or skin.
This medicine may cause sleep-related breathing problems eg, sleep apnea, sleep-related hypoxemia. Your doctor may decrease your dose if you have sleep apnea stop breathing for short periods during sleep while using this medicine.
This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting. Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position.
Getting up slowly may help lessen this problem. Also, lying down for a while may relieve dizziness or lightheadedness. These findings suggest a synergistic interaction between ibuprofen and hydrocodone in a noninflammatory pain model.
Implications: Opioids are frequently used in combination with nonsteroidal antiinflammatory drugs clinically. These studies demonstrate strong interactions between ibuprofen and hydrocodone, implying synergy between the two drugs, which may help explain their utility when given together.
See also How to Use section for more information about addiction. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death. See also Drug Interactions section. Keep this medicine in a safe place to prevent theft, misuse, or abuse. If someone accidentally swallows this drug, get medical help right away. The other ingredient in this medication, ibuprofen, may rarely cause serious rarely fatal bleeding from the stomach or intestines.
Also, nonsteroidal anti-inflammatory drugs including ibuprofen may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater in older adults or if you have heart disease or increased risk for heart disease for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes.
Do not take this drug right before or after heart bypass surgery CABG. Talk to your doctor or pharmacist about the benefits and risks of treatment, as well as other possible medication choices. See also Precautions section.
Before using this medication, women of childbearing age should talk with their doctor s about the benefits and risks. Tell your doctor if you are pregnant or if you plan to become pregnant. It is not recommended for use in pregnancy from 20 weeks until delivery. If your doctor decides that you need to use this medication between 20 and 30 weeks of pregnancy, you should use the lowest effective dose for the shortest possible time. You should not use this medication after 30 weeks of pregnancy.
Babies born to mothers who use this drug for a long time may develop severe possibly fatal withdrawal symptoms. This combination medication is used for a short time usually less than 10 days to help relieve moderate to severe pain.
It contains an opioid pain reliever hydrocodone and a nonsteroidal anti-inflammatory drug-NSAID ibuprofen. Hydrocodone works in the brain to change how your body feels and responds to pain. Ibuprofen reduces pain and fever. Read the Medication Guide provided by your pharmacist before you start using this medication and each time you get a refill.
If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually every 4 to 6 hours as needed. Take it with a full glass of water 8 ounces or milliliters unless your doctor directs you otherwise.
Do not lie down for at least 10 minutes after taking this drug. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea such as lying down for 1 to 2 hours with as little head movement as possible.
The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose, take the medication more frequently, or take it for a longer time than prescribed. Properly stop the medication when so directed. The manufacturer recommends you take no more than 5 tablets in a hour period.
Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well. Also follow your doctor's or pharmacist's directions for the safe use of other non-opioid pain relievers such as acetaminophen. Suddenly stopping this medication may cause withdrawal, especially if you have used it for a long time or in high doses.
To prevent withdrawal, your doctor may lower your dose slowly. Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Opioid Use Pain, Postoperative. Phase 4.
Study Type :. Interventional Clinical Trial. Actual Enrollment :. Actual Study Start Date :. Actual Primary Completion Date :.
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